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Article

Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence.

Molecular and cellular biology - 1 Dec 2002

Inga Alberto, Storici Francesca, Darden Thomas A, Resnick Michael A

Abstract excerpt

Little is known about the mechanisms that regulate differential transactivation by p53. We developed a system in the yeast Saccharomyces cerevisiae that addresses p53 transactivation capacity from 26 different p53 response elements (REs) under conditions where all other factors, such as chromatin, are kept constant. The system relies on a tightly regulated promoter (rheostatable) that can provide for a broad...

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Identifiers

PMID: 12446780
DOI: 10.1128/MCB.22.24.8612-8625.2002
PMCID: PMC139870

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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