Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Low-level p53 expression changes transactivation rules and reveals superactivating sequences

20 Aug 2012

Abstract excerpt

Transcriptional activation by the tumor suppressor p53 is considered to depend on cellular level, although there are few systems where this dependence on cellular level of p53 has been directly addressed. Previously, we reported that transactivation from p53 targets was sensitive to both p53 amount and DNA sequence, with some sequences being responsive to much lower p53 levels than others when examined in yeast...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to RNA modifications and cancer
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22908277
DOI: 10.1073/pnas.1205971109

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Low-level p53 expression changes transactivation rules and reveals superactivating sequencesPMID 22908277Read ↗

Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence.Semantic proximity Read ↗

Noncanonical DNA Motifs as Transactivation Targets by Wild Type and Mutant p53Semantic proximity Read ↗

p53 mutants exhibiting enhanced transcriptional activation and altered promoter selectivity are revealed using a sensitive, yeast-based functional assay.Semantic proximity Read ↗

Functional mutants of the sequence-specific transcription factor p53 and implications for master genes of diversity.Semantic proximity Read ↗

Transactivation specificity is conserved among p53 family proteins and depends on a response element sequence code.Semantic proximity Read ↗

Functionally distinct polymorphic sequences in the human genome that are targets for p53 transactivation.Semantic proximity Read ↗

Altered-function p53 missense mutations identified in breast cancers can have subtle effects on transactivation.Semantic proximity Read ↗

Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cellsSemantic proximity Read ↗

The biological impact of the human master regulator p53 can be altered by mutations that change the spectrum and expression of its target genes.Semantic proximity Read ↗

Analysis of the DNA-binding activity of p53 mutants using functional protein microarrays and its relationship to transcriptional activation.Semantic proximity Read ↗

The versatile interactions of p53 with DNA: when flexibility serves specificity.Semantic proximity Read ↗

Navigating the complexity of p53-DNA binding: implications for cancer therapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.