Article
Mutant p53 proteins bind DNA in a DNA structure-selective mode.
Nucleic acids research - 1 Jan 2005
Göhler Thomas, Jäger Stefan, Warnecke Gabriele, Yasuda Hideyo, Kim Ella, Deppert Wolfgang
Abstract excerpt
Despite the loss of sequence-specific DNA binding, mutant p53 (mutp53) proteins can induce or repress transcription of mutp53-specific target genes. To date, the molecular basis for transcriptional modulation by mutp53 is not understood, but increasing evidence points to the possibility that specific interactions of mutp53 with DNA play an important role. So far, the lack of a common denominator for mutp53 DNA...
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