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Article

Definition of a consensus binding site for p53.

Nature genetics - 1 Apr 1992

el-Deiry W S, Kern S E, Pietenpol J A, Kinzler K W, Vogelstein B

Abstract excerpt

Recent experiments have suggested that p53 action may be mediated through its interaction with DNA. We have now identified 18 human genomic clones that bind to p53 in vitro. Precise mapping of the binding sequences within these clones revealed a consensus binding site with a striking internal symmetry, consisting of two copies of the 10 base pair motif 5'-PuPuPuC(A/T)(T/A)GPyPyPy-3' separated by 0-13 base pairs....

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Identifiers

PMID: 1301998
DOI: 10.1038/ng0492-45

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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