Article
Definition of a consensus binding site for p53.
Nature genetics - 1 Apr 1992
el-Deiry W S, Kern S E, Pietenpol J A, Kinzler K W, Vogelstein B
Abstract excerpt
Recent experiments have suggested that p53 action may be mediated through its interaction with DNA. We have now identified 18 human genomic clones that bind to p53 in vitro. Precise mapping of the binding sequences within these clones revealed a consensus binding site with a striking internal sym...
Topics
- Base Sequence
- Binding Sites
- Cloning, Molecular
- Consensus Sequence
- DNA
- Humans
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Protein Binding
- Tumor Suppressor Protein p53