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Article

Toward rules relating zinc finger protein sequences and DNA binding site preferences.

Proceedings of the National Academy of Sciences of the United States of America - 15 Aug 1992

Desjarlais J R, Berg J M

Abstract excerpt

Zinc finger proteins of the Cys2-His2 type consist of tandem arrays of domains, where each domain appears to contact three adjacent base pairs of DNA through three key residues. We have designed and prepared a series of variants of the central zinc finger within the DNA binding domain of Sp1 by using information from an analysis of a large data base of zinc finger protein sequences. Through systematic variations...

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Identifiers

PMID: 1502144
DOI: 10.1073/pnas.89.16.7345
PMCID: PMC49706

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