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Article

Suppressed epileptogenesis in BDNF mutant mice.

Experimental neurology - 1 Jun 1995

Kokaia M, Ernfors P, Kokaia Z, Elmér E, Jaenisch R, Lindvall O

Abstract excerpt

Kindling is an animal model of epilepsy in which repeated electrical stimulations lead to progressive and permanent amplification of seizure activity, culminating in generalized convulsions. Each brief period of seizure activity during kindling epileptogenesis causes a marked, transient increase of the synthesis of brain-derived neurotrophic factor (BDNF) in cortical and hippocampal neurons. We find that the...

Topics

Animals
Brain
Brain-Derived Neurotrophic Factor
Calcium-Binding Proteins
Epilepsy
Gene Deletion
Kindling, Neurologic
Male
Mice
Mice, Mutant Strains
Mutation
Nerve Growth Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nerve Tissue Proteins

RNA, Messenger

Receptor, Ciliary Neurotrophic Factor

Receptors, Nerve Growth Factor

Source

Identifiers

PMID: 7649227
DOI: 10.1006/exnr.1995.1024

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7649227-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Suppressed epileptogenesis in BDNF mutant mice.PMID 7649227Read ↗

Conditional deletion of TrkB but not BDNF prevents epileptogenesis in the kindling model.Semantic proximity Read ↗

Persistent regional increases in brain-derived neurotrophic factor in the flurothyl model of epileptogenesis are dependent upon the kindling status of the animal.Semantic proximity Read ↗

Chronic fluoxetine treatment accelerates kindling epileptogenesis in mice independently of 5-HT2A receptors.Semantic proximity Read ↗

Mice over-expressing BDNF in forebrain neurons develop an altered behavioral phenotype with age.Semantic proximity Read ↗

Fgf-2 overexpression increases excitability and seizure susceptibility but decreases seizure-induced cell loss.Semantic proximity Read ↗

Audiogenic kindling activates glutamatergic system in the hippocampus of rats with genetic predisposition to audiogenic seizures.Semantic proximity Read ↗

The seizure-related phenotype of brain-derived neurotrophic factor knockdown mice.Semantic proximity Read ↗

BDNF Val66Met impairs fluoxetine-induced enhancement of adult hippocampus plasticity.Semantic proximity Read ↗

BDNF and its pro-peptide are stored in presynaptic dense core vesicles in brain neurons.Semantic proximity Read ↗

Fyn tyrosine kinase is required for normal amygdala kindling.Semantic proximity Read ↗

TrkB/BDNF-dependent striatal plasticity and behavior in a genetic model of epilepsy: modulation by valproic acid.Semantic proximity Read ↗

Deletion of TrkB in adult progenitors alters newborn neuron integration into hippocampal circuits and increases anxiety-like behavior.Semantic proximity Read ↗

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