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Article

Chronic fluoxetine treatment accelerates kindling epileptogenesis in mice independently of 5-HT2A receptors.

Epilepsia - 1 Jul 2018

Li Crystal, Silva Juliana, Ozturk Ezgi, Dezsi Gabriella, O'Brien Terence J, Renoir Thibault, Jones Nigel C

Abstract excerpt

Patients with epilepsy often have mood disorders, and these are commonly treated with antidepressant drugs. Although these drugs are often successful in mitigating depressive symptoms, how they affect the epileptogenic processes has been little studied. Recent evidence has demonstrated that treatment with selective serotonin reuptake inhibitor (SSRI) antidepressant drugs adversely promotes epileptogenesis, which...

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PMID: 29858497
DOI: 10.1111/epi.14435

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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