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Article

Mice over-expressing BDNF in forebrain neurons develop an altered behavioral phenotype with age.

Behavioural brain research - 15 Jul 2014

Weidner Kate L, Buenaventura Diego F, Chadman Kathryn K

Abstract excerpt

Evidence from clinical studies suggests that abnormal activity of brain derived neurotrophic factor (BDNF) contributes to the pathogenesis of autism spectrum disorders (ASDs). A genetically modified line of mice over-expressing a BDNF transgene in forebrain neurons was used to investigate if this mutation leads to changes in behavior consistent with ASD. The mice used in these experiments were behaviorally tested...

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Source

Identifiers

PMID: 24768643
DOI: 10.1016/j.bbr.2014.04.025

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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