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Article

Deletion of TrkB in adult progenitors alters newborn neuron integration into hippocampal circuits and increases anxiety-like behavior.

Proceedings of the National Academy of Sciences of the United States of America - 7 Oct 2008

Bergami Matteo, Rimondini Roberto, Santi Spartaco, Blum Robert, Götz Magdalena, Canossa Marco

Abstract excerpt

New neurons in the adult dentate gyrus are widely held to incorporate into hippocampal circuitry via a stereotypical sequence of morphological and physiological transitions, yet the molecular control over this process remains unclear. We studied the role of brain-derived neurotrophic factor (BDNF)/TrkB signaling in adult neurogenesis by deleting the full-length TrkB via Cre expression within adult progenitors in...

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Identifiers

PMID: 18832146
DOI: 10.1073/pnas.0803702105
PMCID: PMC2557028

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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