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Article

Conditional deletion of TrkB but not BDNF prevents epileptogenesis in the kindling model.

Neuron - 8 Jul 2004

He Xiao-Ping, Kotloski Robert, Nef Serge, Luikart Bryan W, Parada Luis F, McNamara James O

Abstract excerpt

Epileptogenesis is the process whereby a normal brain becomes epileptic. We hypothesized that the neurotrophin brain-derived neurotrophic factor (BDNF) activates its receptor, TrkB, in the hippocampus during epileptogenesis and that BDNF-mediated activation of TrkB is required for epileptogenesis. We tested these hypotheses in Synapsin-Cre conditional BDNF(-/-) and TrkB(-/-) mice using the kindling model. Despite...

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Source

Identifiers

PMID: 15233915
DOI: 10.1016/j.neuron.2004.06.019

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Conditional deletion of TrkB but not BDNF prevents epileptogenesis in the kindling model.PMID 15233915Read ↗

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