Article
TrkB/BDNF-dependent striatal plasticity and behavior in a genetic model of epilepsy: modulation by valproic acid.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jun 2010
Ghiglieri Veronica, Sgobio Carmelo, Patassini Stefano, Bagetta Vincenza, Fejtova Anna, Giampà Carmela, Marinucci Silvia, Heyden Alexandra, Gundelfinger Eckart D, Fusco Francesca R, Calabresi Paolo, Picconi Barbara
Abstract excerpt
In mice lacking the central domain of the presynaptic scaffold Bassoon the occurrence of repeated cortical seizures induces cell-type-specific plasticity changes resulting in a general enhancement of the feedforward inhibition within the striatal microcircuit. Early antiepileptic treatment with valproic acid (VPA) reduces epileptic attacks, inhibits the emergence of pathological form of plasticity in fast-spiking...
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