Article
Audiogenic kindling activates glutamatergic system in the hippocampus of rats with genetic predisposition to audiogenic seizures.
Brain research - 15 Apr 2024
Aleksandrova Ekaterina P, Ivlev Andrey P, Kulikov Alexey A, Naumova Alexandra A, Glazova Margarita V, Chernigovskaya Elena V
Abstract excerpt
Temporal lobe epilepsy (TLE) development is associated with dysregulation of glutamatergic transmission in the hippocampus; however, detailed molecular mechanisms of pathological changes are still poorly understood. In the present study, we performed the complex analysis of glutamatergic system in the hippocampus of Krushinsky-Molodkina (KM) rats genetically prone to audiogenic seizures (AGS). Daily AGS...
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