Isolation of mutant T lymphocytes with defects in capacitative calcium entry.

Abstract excerpt

Calcium and calcium-binding proteins play important roles in the signaling cascade leading from the initial engagement of TCRs on T cells to the fully activated state. To undertake a molecular dissection of this cascade, we first isolated a Jurkat T cell line derivative containing the NF-AT promoter element driving transcription of the diphtheria toxin A chain gene (dipA), resulting in rapid cell death. Selecting...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Base Sequence
• Share to Cell Line
• Share to DNA-Binding Proteins