Isolation of mutant T lymphocytes with defects in capacitative calcium entry.

doi:10.1016/1074-7613(95)90093-4

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Isolation of mutant T lymphocytes with defects in capacitative calcium entry.

Immunity - 1 Aug 1995

Serafini A T, Lewis R S, Clipstone N A, Bram R J, Fanger C, Fiering S, Herzenberg L A, Crabtree G R

Abstract excerpt

Calcium and calcium-binding proteins play important roles in the signaling cascade leading from the initial engagement of TCRs on T cells to the fully activated state. To undertake a molecular dissection of this cascade, we first isolated a Jurkat T cell line derivative containing the NF-AT promo...

Topics

Base Sequence
Calcineurin
Calcium
Calmodulin-Binding Proteins
Cell Compartmentation
Cell Line
Cell Nucleus
DNA-Binding Proteins
Gene Expression Regulation
Humans
Lymphocyte Activation
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

NFATC Transcription Factors

Nuclear Proteins

Oligodeoxyribonucleotides

Phosphoprotein Phosphatases

T-Lymphocytes

Source

Open in PubMed

Identifiers

PMID: 7648396
DOI: 10.1016/1074-7613(95)90093-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7648396-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Isolation of mutant T lymphocytes with defects in capacitative calcium entry.PMID 7648396Read ↗

Characterization of T cell mutants with defects in capacitative calcium entry: genetic evidence for the physiological roles of CRAC channels.Semantic proximity Read ↗

Mutation of an L-Type Calcium Channel Gene Leads to T Lymphocyte Dysfunction.Semantic proximity Read ↗

Characterization of a mutant T-cell hybridoma line with defects in the TCR-mediated apoptotic pathway.Semantic proximity Read ↗

Requirement of voltage-gated calcium channel beta4 subunit for T lymphocyte functions.Semantic proximity Read ↗

Ryanodine receptor 1 is dispensable for CD4 <sup>+</sup> T-cell differentiation and effector function in intestinal inflammation modelsSemantic proximity Read ↗

Coupling Ca2+ store release to Icrac channel activation in B lymphocytes requires the activity of Lyn and Syk kinases.Semantic proximity Read ↗

Mutant T cell lines as model systems for the dissection of T cell antigen receptor signaling pathways.Semantic proximity Read ↗

LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway.Semantic proximity Read ↗

Mutants in signal transduction through the T-cell antigen receptor.Semantic proximity Read ↗

Measurement of intracellular calcium ions by flow cytometry.Semantic proximity Read ↗

Constitutively active adenylyl cyclase mutant requires neither G proteins nor cytosolic regulators.Semantic proximity Read ↗

Study of T-cell signaling by somatic cell mutagenesis and complementation cloning.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.