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Article

Coupling Ca2+ store release to Icrac channel activation in B lymphocytes requires the activity of Lyn and Syk kinases.

The Journal of cell biology - 23 Apr 2007

Chung S Clare, Limnander Andre, Kurosaki Tomohiro, Weiss Arthur, Korenbrot Juan I

Abstract excerpt

Activation of the B cell receptor complex in B lymphocytes causes Ca(2+) release from intracellular stores, which, in turn, activates ion channels known as Icrac. We investigated the mechanisms that link Ca(2+) store release to channel gating in DT40 B lymphocyte cell lines genetically manipulated to suppress the expression of several tyrosine kinases: Btk, Lyn, Syk, and the Blnk adaptor molecule. The...

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Identifiers

PMID: 17452533
DOI: 10.1083/jcb.200702050
PMCID: PMC2064139

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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