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Article

Study of T-cell signaling by somatic cell mutagenesis and complementation cloning.

Journal of immunological methods - 1 Jul 2003

Cvijic Mary Ellen, Xiao Gutian, Sun Shao-Cong

Abstract excerpt

Somatic cell mutagenesis is a powerful genetic approach used in dissection of signal transduction pathways in mammalian cells. Here we describe a method that has been successfully used to identify and analyze components of the NF-kappaB signaling pathway in Jurkat T cells using the combination of somatic cell mutagenesis and a complementation cloning strategy. By treating Jurkat T cells with the chemical mutagen...

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PMID: 12957416
DOI: 10.1016/s0022-1759(03)00191-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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