Article
LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway.
Immunity - 1 Nov 1998
Finco T S, Kadlecek T, Zhang W, Samelson L E, Weiss A
Abstract excerpt
In this study, we present the further characterization of a mutant Jurkat T cell line, J.CaM2, that is defective in TCR-mediated signal transduction. Although initial TCR-mediated signaling events such as the inducible tyrosine phosphorylation of the TCR-zeta chain and ZAP-70 are intact in J.CaM2...
Topics
- Adaptor Proteins, Signal Transducing
- Antigens, CD
- Antigens, Differentiation, T-Lymphocyte
- Calcium
- Calcium-Calmodulin-Dependent Protein Kinases
- Carrier Proteins
- DNA-Binding Proteins
- Enzyme Activation
- Gene Expression Regulation
- Humans
- Interleukin-2
- Isoenzymes
- Jurkat Cells
- Lectins, C-Type
- Membrane Proteins
- Mutation
- NFATC Transcription Factors
- Nuclear Proteins