Article
LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway.
Immunity - 1 Nov 1998
Finco T S, Kadlecek T, Zhang W, Samelson L E, Weiss A
Abstract excerpt
In this study, we present the further characterization of a mutant Jurkat T cell line, J.CaM2, that is defective in TCR-mediated signal transduction. Although initial TCR-mediated signaling events such as the inducible tyrosine phosphorylation of the TCR-zeta chain and ZAP-70 are intact in J.CaM2, subsequent events, including increases in intracellular calcium, Ras activation, and IL-2 gene expression are...
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