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Article

Characterization of T cell mutants with defects in capacitative calcium entry: genetic evidence for the physiological roles of CRAC channels.

The Journal of cell biology - 1 Nov 1995

Fanger C M, Hoth M, Crabtree G R, Lewis R S

Abstract excerpt

Prolonged Ca2+ influx is an essential signal for the activation of T lymphocytes by antigen. This influx is thought to occur through highly selective Ca2+ release-activated Ca2+ (CRAC) channels that are activated by the depletion of intracellular Ca2+ stores. We have isolated mutants of the Jurkat human T cell line NZdipA to explore the molecular mechanisms that underlie capacitative Ca2+ entry and to allow a...

Topics

Calcium
Calcium Channels
Cell Fusion
Cell Line
Electric Conductivity
Electrophysiology
Humans
Lymphoma
Mutation
Potassium Channels
T-Lymphocytes

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Transcription, Genetic

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Identifiers

PMID: 7593187
DOI: 10.1083/jcb.131.3.655
PMCID: PMC2120614

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7593187-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Characterization of T cell mutants with defects in capacitative calcium entry: genetic evidence for the physiological roles of CRAC channels.PMID 7593187Read ↗

Isolation of mutant T lymphocytes with defects in capacitative calcium entry.Semantic proximity Read ↗

Biallelic mutations in calcium release activated channel regulator 2A (CRACR2A) cause a primary immunodeficiency disorder.Semantic proximity Read ↗

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