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Article

The insulin-like growth factor I receptor is required for Akt activation and suppression of anoikis in cells transformed by the ETV6-NTRK3 chimeric tyrosine kinase.

Molecular and cellular biology - 1 Mar 2006

Martin Matthew J, Melnyk Nataliya, Pollard Michelle, Bowden Mary, Leong Hon, Podor Thomas J, Gleave Martin, Sorensen Poul H B

Abstract excerpt

Signaling through the insulin-like growth factor I receptor (IGF-IR) axis is essential for transformation by many dominantly acting oncoproteins. However, the mechanism by which IGF-IR contributes to oncogenesis remains unknown. To examine this, we compared transformation properties of the oncogenic ETV6-NTRK3 (EN) chimeric tyrosine kinase in IGF-IR-null R- mouse embryo fibroblasts with R- cells engineered to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Oncogene Proteins, Fusion

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Source

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Identifiers

PMID: 16478996
DOI: 10.1128/MCB.26.5.1754-1769.2006
PMCID: PMC1430251

Genes

ETV6
NTRK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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