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Article

Transformation of late passage insulin-like growth factor-I receptor null mouse embryo fibroblasts by SV40 T antigen.

Cancer research - 15 Apr 2006

Spence Susan L, Shaffer Arthur L, Staudt Louis M, Amde Sewit, Manney Sutana, Terry Cheryl, Weisz Keith, Nissley Peter

Abstract excerpt

There is evidence that the insulin-like growth factor-I (IGF-I) receptor is required for transformation by a variety of viral and cellular oncogenes in a mouse embryo fibroblast model. To further investigate the IGF-I receptor signaling pathways that are required for the permissive effect of the receptor on transformation by SV40 T antigen, we established three independent fibroblast cell lines each from...

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Share to Antigens, Polyomavirus Transforming
Share to Cell Growth Processes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Embryo, Mammalian

Share to Focal Adhesion Kinase 1

Share to GRB2 Adaptor Protein

Share to Insulin Receptor Substrate Proteins

Share to Receptor, ErbB-3

Share to Receptor, IGF Type 1

Source

Identifiers

PMID: 16618746
DOI: 10.1158/0008-5472.CAN-05-2257

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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