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Article

Transformation by the simian virus 40 T antigen is regulated by IGF-I receptor and IRS-1 signaling.

Oncogene - 5 Jan 2006

DeAngelis T, Chen J, Wu A, Prisco M, Baserga R

Abstract excerpt

Previous work has shown that the Simian Virus 40 T antigen (T antigen) cannot transform mouse embryo fibroblasts (MEFs) that do not express the type 1 insulin-like growth factor receptor (IGF-IR). We have now investigated the mechanism(s) by which the transforming activity of T antigen is affected by IGF-IR signaling. We demonstrate that transformation by T antigen of MEFs and several other cell lines requires an...

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Identifiers

PMID: 16170362
DOI: 10.1038/sj.onc.1209013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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