Phenotypic and genomic analysis of serotype 3 Sabin poliovirus vaccine produced in MRC-5 cell substrate.

doi:10.1002/jmv.21804

Back to search

Article

Phenotypic and genomic analysis of serotype 3 Sabin poliovirus vaccine produced in MRC-5 cell substrate.

Journal of medical virology - 1 May 2011

Alirezaie Behnam, Taqavian Mohammad, Aghaiypour Khosrow, Esna-Ashari Fatemeh, Shafyi Abbas

Abstract excerpt

The cell substrate has a pivotal role in live virus vaccines production. It is necessary to evaluate the effects of the cell substrate on the properties of the propagated viruses, especially in the case of viruses which are unstable genetically such as polioviruses, by monitoring the molecular an...

Topics

Cell Culture Techniques
Cell Line
Genome, Viral
Genomic Instability
Humans
Mutation
Poliovirus
Poliovirus Vaccines
RNA, Viral
Sequence Analysis, DNA

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.