Article
Correlation of mutations and recombination with growth kinetics of poliovirus vaccine strains.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology - 1 Dec 2010
Pliaka V, Kyriakopoulou Z, Tsakogiannis D, Ruether I G A, Gartzonika C, Levidiotou-Stefanou S, Krikelis A, Markoulatos P
Abstract excerpt
Attenuated strains of Sabin poliovirus vaccine replicate in the human gut and, in rare cases, may cause vaccine-associated paralytic poliomyelitis (VAPP). The genetic instability of Sabin strains constitutes one of the main causes of VAPP, a disease that is most frequently associated with type 3...
Topics
- Cell Line
- Genome, Viral
- Humans
- Kinetics
- Mutation
- Poliovirus
- Poliovirus Vaccine, Oral
- RNA, Viral
- Recombination, Genetic
- Sequence Analysis, DNA
- Temperature
- Vaccines, Attenuated