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Article

Insulin-like growth factor I receptor activated by a transmembrane mutation.

The Journal of biological chemistry - 11 Aug 1995

Takahashi K, Yonezawa K, Nishimoto I

Abstract excerpt

We constructed mutant receptors by mutating transmembrane Val922 of the human insulin-like growth factor I receptor (IGF-IR). Assays of receptor kinase and autophosphorylation revealed constitutively augmented tyrosine kinase activity of V922E IGF-IR in both transient and stable expression. The constitutively active tyrosine kinase of this mutant was verified by promoted tyrosine phosphorylation of insulin...

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PMID: 7642566
DOI: 10.1074/jbc.270.32.19041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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