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Article

Insulin-like growth factor I receptor activated by a transmembrane mutation.

The Journal of biological chemistry - 11 Aug 1995

Takahashi K, Yonezawa K, Nishimoto I

Abstract excerpt

We constructed mutant receptors by mutating transmembrane Val922 of the human insulin-like growth factor I receptor (IGF-IR). Assays of receptor kinase and autophosphorylation revealed constitutively augmented tyrosine kinase activity of V922E IGF-IR in both transient and stable expression. The constitutively active tyrosine kinase of this mutant was verified by promoted tyrosine phosphorylation of insulin...

Topics

Animals
Base Sequence
CHO Cells
Cell Division
Cricetinae
Molecular Sequence Data
Mutation
Phosphatidylinositol 3-Kinases
Phosphorylation
Phosphotransferases (Alcohol Group Acceptor)
Receptor Protein-Tyrosine Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptor, IGF Type 1

Source

Identifiers

PMID: 7642566
DOI: 10.1074/jbc.270.32.19041

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7642566-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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