Article
Converting Insulin-like Growth Factors 1 and 2 into High-Affinity Ligands for Insulin Receptor Isoform A by the Introduction of an Evolutionarily Divergent Mutation.
Biochemistry - 24 Apr 2018
Macháčková Kateřina, Chrudinová Martina, Radosavljević Jelena, Potalitsyn Pavlo, Křížková Květoslava, Fábry Milan, Selicharová Irena, Collinsová Michaela, Brzozowski Andrzej M, Žáková Lenka, Jiráček Jiří
Abstract excerpt
Insulin-like growth factors 1 and 2 (IGF-1 and -2, respectively) are protein hormones involved not only in normal growth and development but also in life span regulation and cancer. They exert their functions mainly through the IGF-1R or by binding to isoform A of the insulin receptor (IR-A). The development of IGF-1 and IGF-2 antagonists is of great clinical interest. Mutations of A4 and A8 sites of human...
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