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Article

Evidence supporting a passive role for the insulin receptor transmembrane domain in insulin-dependent signal transduction.

The Journal of biological chemistry - 25 May 1991

Frattali A L, Treadway J L, Pessin J E

Abstract excerpt

We previously have demonstrated that intramolecular interactions between alpha beta-alpha beta subunits are necessary for insulin-dependent activation of the protein kinase domain within a single alpha 2 beta 2 heterotetrameric insulin-receptor complex (Wilden, P. A., Morrison, B. D., and Pessin, J. E. (1989) Biochemistry 28, 785-792). To evaluate the role of the beta subunit transmembrane domain in the...

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PMID: 2033070

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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