Article
Evidence supporting a passive role for the insulin receptor transmembrane domain in insulin-dependent signal transduction.
The Journal of biological chemistry - 25 May 1991
Frattali A L, Treadway J L, Pessin J E
Abstract excerpt
We previously have demonstrated that intramolecular interactions between alpha beta-alpha beta subunits are necessary for insulin-dependent activation of the protein kinase domain within a single alpha 2 beta 2 heterotetrameric insulin-receptor complex (Wilden, P. A., Morrison, B. D., and Pessin,...
Topics
- Amino Acid Sequence
- Animals
- Cell Membrane
- Cricetinae
- Cricetulus
- Cross-Linking Reagents
- Electrophoresis, Polyacrylamide Gel
- Gene Expression Regulation
- Humans
- Insulin
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Plasmids
- RNA, Messenger
- Receptor, Insulin
- Signal Transduction
- Substrate Specificity