Article
A mutation in the extracellular domain of the insulin receptor impairs the ability of insulin to stimulate receptor autophosphorylation.
The Journal of biological chemistry - 5 Jan 1991
Accili D, Mosthaf L, Ullrich A, Taylor S I
Abstract excerpt
Mutations of the insulin receptor gene have been shown to cause insulin-resistant diabetes in patients with genetic forms of insulin resistance. We have previously reported that a mutation substituting valine for Phe382 in the alpha-subunit of the insulin receptor is associated with impaired transport of the mutant receptor to the plasma membrane (Accili, D., Frapier, C., Mosthaf, L., McKeon, C., Elbein, S. C.,...
Topics
- Animals
- Cell Line
- Humans
- Infant
- Insulin
- Kinetics
- Mice
- Mice, Inbred Strains
- Mutation
- Peptide Mapping
- Phosphopeptides
- Phosphorylation