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Article

Distinct and overlapping functions of insulin and IGF-I receptors.

Endocrine reviews - 1 Dec 2001

Nakae J, Kido Y, Accili D

Abstract excerpt

Targeted gene mutations have established distinct, yet overlapping, developmental roles for receptors of the insulin/IGF family. IGF-I receptor mediates IGF-I and IGF-II action on prenatal growth and IGF-I action on postnatal growth. Insulin receptor mediates prenatal growth in response to IGF-II and postnatal metabolism in response to insulin. In rodents, unlike humans, insulin does not participate in embryonic...

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Source

Identifiers

PMID: 11739335
DOI: 10.1210/edrv.22.6.0452

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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