Genomic organization and molecular genetics of the agouti locus in the mouse.

doi:10.1111/j.1749-6632.1991.tb24406.x

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Article

Genomic organization and molecular genetics of the agouti locus in the mouse.

Annals of the New York Academy of Sciences - 26 Dec 1991

Siracusa L D

Abstract excerpt

The agouti locus regulates a switch in pigment synthesis by hair bulb melanocytes between eumelanosomes and phaeomelanosomes. The agouti locus appears to encode a trans-acting product that acts within the hair follicle to direct the pigment synthesis of melanocytes. In addition to coat color, sev...

Topics

Alleles
Animals
Chromosome Mapping
Genes, Lethal
Genes, Recessive
Genetic Complementation Test
Genetic Linkage
Genome
Hair Color
Mice
Mice, Inbred Strains
Mice, Mutant Strains

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