Article
Genomic organization and molecular genetics of the agouti locus in the mouse.
Annals of the New York Academy of Sciences - 26 Dec 1991
Siracusa L D
Abstract excerpt
The agouti locus regulates a switch in pigment synthesis by hair bulb melanocytes between eumelanosomes and phaeomelanosomes. The agouti locus appears to encode a trans-acting product that acts within the hair follicle to direct the pigment synthesis of melanocytes. In addition to coat color, several agouti mutations affect development, obesity, and susceptibility to neoplasms. The genomic organization of the...
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