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Article

Opposite orientations of an inverted duplication and allelic variation at the mouse agouti locus.

Genetics - 1 Sept 1996

Chen Y, Duhl D M, Barsh G S

Abstract excerpt

The mouse agouti protein is a paracrine signaling molecule that causes yellow pigment synthesis. A pale ventral coloration distinguishes the light-bellied agouti (AW) from the agouti (A) allele, and is caused by expression of ventral-specific mRNA isoforms with a unique 5' untranslated exon. Molecular cloning demonstrates this ventral-specific exon lies within a 3.1-kb element that is duplicated in the opposite...

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PMID: 8878692
DOI: 10.1093/genetics/144.1.265
PMCID: PMC1207500

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