Article
Influence of second and third cytoplasmic loops on binding, internalization, and coupling of chimeric bombesin/m3 muscarinic receptors.
The Journal of biological chemistry - 28 Jul 1995
Tseng M J, Coon S, Stuenkel E, Struk V, Logsdon C D
Abstract excerpt
In order to investigate the molecular basis for differences in the characteristics of bombesin (Bn) and m3 muscarinic cholinergic (m3 ACh) receptors, chimeric Bn receptors possessing cytoplasmic domains from the m3 ACh receptor were produced. The receptors were expressed in CHO-K1 cells and bindi...
Topics
- Animals
- Base Sequence
- CHO Cells
- Cricetinae
- Cytoplasm
- DNA Primers
- Endocytosis
- Molecular Sequence Data
- Mutation
- Protein Binding
- Receptors, Bombesin
- Receptors, Muscarinic
- Recombinant Fusion Proteins
- Second Messenger Systems