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Article

Influence of second and third cytoplasmic loops on binding, internalization, and coupling of chimeric bombesin/m3 muscarinic receptors.

The Journal of biological chemistry - 28 Jul 1995

Tseng M J, Coon S, Stuenkel E, Struk V, Logsdon C D

Abstract excerpt

In order to investigate the molecular basis for differences in the characteristics of bombesin (Bn) and m3 muscarinic cholinergic (m3 ACh) receptors, chimeric Bn receptors possessing cytoplasmic domains from the m3 ACh receptor were produced. The receptors were expressed in CHO-K1 cells and binding, structural, and signal transduction characteristics were analyzed. Cell lines bearing chimeric Bn receptors...

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Identifiers

PMID: 7629092
DOI: 10.1074/jbc.270.30.17884

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Influence of second and third cytoplasmic loops on binding, internalization, and coupling of chimeric bombesin/m3 muscarinic receptors.PMID 7629092Read ↗

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Internalization of the Hm1 muscarinic cholinergic receptor involves the third cytoplasmic loop.Semantic proximity Read ↗

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Distinct sequence elements control the specificity of G protein activation by muscarinic acetylcholine receptor subtypes.Semantic proximity Read ↗

Evidence for cross-talk between M2 and M3 muscarinic acetylcholine receptors in the regulation of second messenger and extracellular signal-regulated kinase signalling pathways in Chinese hamster ovary cells.Semantic proximity Read ↗

Mutation of carboxyl-terminal threonine residues in human m3 muscarinic acetylcholine receptor modulates the extent of sequestration and desensitization.Semantic proximity Read ↗

Muscarinic M4 receptor recycling requires a motif in the third intracellular loop.Semantic proximity Read ↗

Residues specifically involved in down-regulation but not internalization of the m1 muscarinic acetylcholine receptor.Semantic proximity Read ↗

Human m3 muscarinic acetylcholine receptor carboxyl-terminal threonine resides are required for agonist-induced receptor down-regulation.Semantic proximity Read ↗

Activation of a GTP-binding protein and a GTP-binding-protein-coupled receptor kinase (beta-adrenergic-receptor kinase-1) by a muscarinic receptor m2 mutant lacking phosphorylation sites.Semantic proximity Read ↗

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