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Article

Muscarinic M4 receptor recycling requires a motif in the third intracellular loop.

The Journal of pharmacology and experimental therapeutics - 1 Jun 2008

Hashimoto Yuichi, Morisawa Kanoko, Saito Hiroyuki, Jojima Eri, Yoshida Norihiro, Haga Tatsuya

Abstract excerpt

The present study was performed to identify sequence(s) in the third intracellular loop (i3) of the muscarinic acetylcholine receptor M4 subtype (M4 receptor) involved in its internalization and recycling. In transiently transfected human embryonic kidney 293-tsA201 cells, 40 to 50% of cell-surface M4 receptors are internalized in an agonist-dependent manner, and approximately 65% of internalized receptors are...

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Identifiers

PMID: 18337477
DOI: 10.1124/jpet.107.135095

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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