Article
Differential regulation of muscarinic M1 and M3 receptors by a putative phosphorylation domain.
European journal of pharmacology - 14 Jul 1999
Shockley M S, Tolbert L M, Tobin A B, Nahorski S R, Sadée W, Lameh J
Abstract excerpt
A motif consisting of several serine residues flanked N-terminally by acidic residues occurs in the third intracellular loop of both muscarinic M1 and M3 receptors (287SerLeuThrSerSer291 and 349SerAlaSerSer352, respectively). We examined the role of these domains in modulating agonist-induced desensitization and receptor trafficking, and for the muscarinic M3 receptor, we assessed the contribution of...
Topics
- Animals
- Binding Sites
- Binding, Competitive
- CHO Cells
- Carbachol
- Cricetinae
- Down-Regulation
- Fluorescent Antibody Technique, Indirect
- Gene Expression
- Humans
- Inositol 1,4,5-Trisphosphate
- Microscopy, Confocal
- Muscarinic Agonists
- Mutation