Article
Internalization of the Hm1 muscarinic cholinergic receptor involves the third cytoplasmic loop.
FEBS letters - 3 Sept 1990
Maeda S, Lameh J, Mallet W G, Philip M, Ramachandran J, Sadée W
Abstract excerpt
The m1 muscarinic receptor was previously shown to stimulate phosphatidyl inositol (PI) turnover and to internalize rapidly upon agonist activation. Three receptor mutants with large deletions of the third cytoplasmic loop (i3) of human Hm1, leaving only 11 and 8 amino acids at the amino and carboxy terminal junctions of i3, respectively, retained full ability to stimulate PI turnover, when expressed in U293...
Topics
- Carbachol
- Cell Line
- Chromosome Deletion
- Cytoplasm
- Female
- Genetic Vectors
- Genomic Library
- Humans
- Mutation
- Phosphatidylinositols
- Placenta
- Pregnancy