Human m3 muscarinic acetylcholine receptor carboxyl-terminal threonine resides are required for agonist-induced receptor down-regulation.

Article

Human m3 muscarinic acetylcholine receptor carboxyl-terminal threonine resides are required for agonist-induced receptor down-regulation.

Molecular pharmacology - 1 Dec 1993

Yang J, Logsdon C D, Johansen T E, Williams J A

Abstract excerpt

The mechanisms involved in agonist-induced down-regulation of the human m3 muscarinic acetylcholine receptor were investigated by site-directed mutagenesis of the receptor cytoplasmic carboxyl terminus. Threonine residues (Thr550,553,554) were converted into alanines collectively and individually...

Topics

Binding Sites
Culture Techniques
Down-Regulation
Humans
Hydrolysis
Ligands
Mutation
Phosphatidylinositols
Receptors, Muscarinic
Signal Transduction
Threonine

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