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Article

Human m3 muscarinic acetylcholine receptor carboxyl-terminal threonine resides are required for agonist-induced receptor down-regulation.

Molecular pharmacology - 1 Dec 1993

Yang J, Logsdon C D, Johansen T E, Williams J A

Abstract excerpt

The mechanisms involved in agonist-induced down-regulation of the human m3 muscarinic acetylcholine receptor were investigated by site-directed mutagenesis of the receptor cytoplasmic carboxyl terminus. Threonine residues (Thr550,553,554) were converted into alanines collectively and individually. The mutated and wild-type receptor cDNAs stably expressed in Chinese hamster ovary cells displayed similar...

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PMID: 8264552

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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