Article
Internalization of the gastrin-releasing peptide receptor is mediated by both phospholipase C-dependent and -independent processes.
Molecular pharmacology - 1 Sept 1994
Benya R V, Akeson M, Mrozinski J, Jensen R T, Battey J F
Abstract excerpt
Consequent to agonist exposure, many G protein-coupled receptors undergo sequestration or internalization. Results with receptors linked to adenylate cyclase, such as the beta 2-adrenergic receptor, or receptors linked to phospholipase C (PLC) have provided conflicting results regarding the role of second messenger-dependent (i.e., protein kinase A or C) and -independent (i.e., beta-adrenergic receptor kinase)...
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