Chimeric muscarinic cholinergic: beta-adrenergic receptors that activate Gs in response to muscarinic agonists.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Chimeric muscarinic cholinergic: beta-adrenergic receptors that activate Gs in response to muscarinic agonists.

The Journal of biological chemistry - 15 Apr 1990

Wong S K, Parker E M, Ross E M

Abstract excerpt

The M1-muscarinic cholinergic receptor (M1AChR) stimulates the release of inositol phosphates (IPs) but does not activate adenylyl cyclase. The beta-adrenergic receptor (beta-AR) stimulates adenylyl cyclase but has no effect on IP release. Amino acid sequences corresponding to the second (I2) and third (I3) intracellular loops of the turkey erythrocyte beta-AR and a 12-amino acid segment near the N-terminal end...

Topics

Adenylyl Cyclases
Amino Acid Sequence
Animals
Cell Line
Chimera
Enzyme Activation
GTP-Binding Proteins
Inositol Phosphates
Kinetics
Models, Molecular
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Oligonucleotide Probes

Protein Conformation

Receptors, Adrenergic, beta

Receptors, Muscarinic

Transfection

Source

Open in PubMed

Identifiers

PMID: 2156845

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2156845-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chimeric muscarinic cholinergic: beta-adrenergic receptors that activate Gs in response to muscarinic agonists.PMID 2156845Read ↗

Coupling of a mutated form of the human beta 2-adrenergic receptor to Gi and Gs. Requirement for multiple cytoplasmic domains in the coupling process.Semantic proximity Read ↗

Internalization of the Hm1 muscarinic cholinergic receptor involves the third cytoplasmic loop.Semantic proximity Read ↗

Distinct sequence elements control the specificity of G protein activation by muscarinic acetylcholine receptor subtypes.Semantic proximity Read ↗

Hm1 muscarinic cholinergic receptor internalization requires a domain in the third cytoplasmic loop.Semantic proximity Read ↗

Influence of second and third cytoplasmic loops on binding, internalization, and coupling of chimeric bombesin/m3 muscarinic receptors.Semantic proximity Read ↗

Targeted inactivation of alphai2 or alphai3 disrupts activation of the cardiac muscarinic K+ channel, IK+Ach, in intact cells.Semantic proximity Read ↗

A truncation mutation in the avian beta-adrenergic receptor causes agonist-induced internalization and GTP-sensitive agonist binding characteristic of mammalian receptors.Semantic proximity Read ↗

Internalization of the gastrin-releasing peptide receptor is mediated by both phospholipase C-dependent and -independent processes.Semantic proximity Read ↗

Functional Expression of Adenosine A3 Receptor in Yeast Utilizing a Chimera with the A2AR C-Terminus.Semantic proximity Read ↗

Distinct receptor domains determine subtype-specific coupling and desensitization phenotypes for human beta1- and beta2-adrenergic receptors.Semantic proximity Read ↗

Critical regions for activation gating of the inositol 1,4,5-trisphosphate receptor.Semantic proximity Read ↗

Lack of constitutive activation or inactivation of the platelet-activating factor receptor by glutamate substitution of alanine 230.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.