Article
Residues specifically involved in down-regulation but not internalization of the m1 muscarinic acetylcholine receptor.
Journal of neurochemistry - 1 Feb 1997
Shockley M S, Burford N T, Sadée W, Lameh J
Abstract excerpt
Human m1 muscarinic acetylcholine receptor mutants were screened to determine receptor domains and cellular pathways relevant to down-regulation. Mutations in the second intracellular loop and the junctions of the third intracellular loop of the receptor, where a role for receptor activation or i...
Topics
- Adenylyl Cyclases
- Animals
- CHO Cells
- Carbachol
- Cricetinae
- Down-Regulation
- Endocytosis
- GTP-Binding Proteins
- Gene Expression
- Guanosine 5'-O-(3-Thiotriphosphate)
- Guanosine Triphosphate
- Humans
- Inositol Phosphates
- Microscopy, Confocal
- Muscarinic Agonists
- Mutation
- Receptors, Cell Surface
- Receptors, Muscarinic