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Article

Residues specifically involved in down-regulation but not internalization of the m1 muscarinic acetylcholine receptor.

Journal of neurochemistry - 1 Feb 1997

Shockley M S, Burford N T, Sadée W, Lameh J

Abstract excerpt

Human m1 muscarinic acetylcholine receptor mutants were screened to determine receptor domains and cellular pathways relevant to down-regulation. Mutations in the second intracellular loop and the junctions of the third intracellular loop of the receptor, where a role for receptor activation or internalization had been previously demonstrated in HEK293 cells, were selected for this study. To assess receptor...

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Identifiers

PMID: 9003046
DOI: 10.1046/j.1471-4159.1997.68020601.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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