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Article

Mutation of carboxyl-terminal threonine residues in human m3 muscarinic acetylcholine receptor modulates the extent of sequestration and desensitization.

Molecular pharmacology - 1 Sept 1995

Yang J, Williams J A, Yule D I, Logsdon C D

Abstract excerpt

We previously reported that a mutant human m3 muscarinic acetylcholine receptor in which threonine residues at positions 550, 553, and 554 in the carboxyl terminus had been substituted with alanines showed a significant blockage of receptor down-regulation when expressed in Chinese hamster ovary-K1 cells. Because Chinese hamster ovary cells showed little receptor sequestration, in the present study we...

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PMID: 7565628

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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