Article
Evidence for cross-talk between M2 and M3 muscarinic acetylcholine receptors in the regulation of second messenger and extracellular signal-regulated kinase signalling pathways in Chinese hamster ovary cells.
British journal of pharmacology - 1 Apr 2003
Hornigold David C, Mistry Rajendra, Raymond Pamela D, Blank Jonathan L, Challiss R A John
Abstract excerpt
1. We have examined possible mechanisms of cross-talk between the G(q/11)-linked M(3) muscarinic acetylcholine (mACh) receptor and the G(i/o)-linked M(2) mACh receptor by stable receptor coexpression in Chinese hamster ovary (CHO) cells. A number of second messenger (cyclic AMP, Ins(1,4,5)P(3)) and mitogen-activated protein kinase (ERK and JNK) responses stimulated by the mACh receptor agonist methacholine were...
Topics
- Animals
- CHO Cells
- Cricetinae
- Humans
- JNK Mitogen-Activated Protein Kinases
- Mitogen-Activated Protein Kinases
- Mutation
- Receptor Cross-Talk
- Receptor, Muscarinic M2
- Receptor, Muscarinic M3
- Receptors, Cell Surface
- Second Messenger Systems