Article
Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis.
Cell - 28 Jul 1995
Baker S M, Bronner C E, Zhang L, Plug A W, Robatzek M, Warren G, Elliott E A, Yu J, Ashley T, Arnheim N, Flavell R A, Liskay R M
Abstract excerpt
Using gene targeting in embryonic stem cells, we have derived mice with a null mutation in a DNA mismatch repair gene homolog, PMS2. We observed microsatellite instability in the male germline, in tail, and in tumor DNA of PMS2-deficient animals. We therefore conclude that PMS2 is involved in DNA...
Topics
- Adenosine Triphosphatases
- Alleles
- Amino Acid Sequence
- Animals
- Base Composition
- Base Sequence
- Chromosome Aberrations
- Chromosome Disorders
- Cloning, Molecular
- DNA
- DNA Primers
- DNA Repair
- DNA Repair Enzymes
- DNA-Binding Proteins