Article
The budding yeast Msh4 protein functions in chromosome synapsis and the regulation of crossover distribution.
Genetics - 1 Jul 2001
Novak J E, Ross-Macdonald P B, Roeder G S
Abstract excerpt
The budding yeast MSH4 gene encodes a MutS homolog produced specifically in meiotic cells. Msh4 is not required for meiotic mismatch repair or gene conversion, but it is required for wild-type levels of crossing over. Here, we show that a msh4 null mutation substantially decreases crossover interference. With respect to the defect in interference and the level of crossing over, msh4 is similar to the zip1 mutant,...
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