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Article

PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance.

Proceedings of the National Academy of Sciences of the United States of America - 27 Jul 2010

van Oers Johanna M M, Roa Sergio, Werling Uwe, Liu Yiyong, Genschel Jochen, Hou Harry, Sellers Rani S, Modrich Paul, Scharff Matthew D, Edelmann Winfried

Abstract excerpt

The DNA mismatch repair protein PMS2 was recently found to encode a novel endonuclease activity. To determine the biological functions of this activity in mammals, we generated endonuclease-deficient Pms2E702K knock-in mice. Pms2EK/EK mice displayed increased genomic mutation rates and a strong cancer predisposition. In addition, class switch recombination, but not somatic hypermutation, was impaired in Pms2EK/EK...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20624957
DOI: 10.1073/pnas.1008589107
PMCID: PMC2922181

Genes

PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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