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Article

Mouse SYCP2 is required for synaptonemal complex assembly and chromosomal synapsis during male meiosis.

The Journal of cell biology - 22 May 2006

Yang Fang, De La Fuente Rabindranath, Leu N Adrian, Baumann Claudia, McLaughlin K John, Wang P Jeremy

Abstract excerpt

During meiosis, the arrangement of homologous chromosomes is tightly regulated by the synaptonemal complex (SC). Each SC consists of two axial/lateral elements (AEs/LEs), and numerous transverse filaments. SC protein 2 (SYCP2) and SYCP3 are integral components of AEs/LEs in mammals. We find that SYCP2 forms heterodimers with SYCP3 both in vitro and in vivo. An evolutionarily conserved coiled coil domain in SYCP2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16717126
DOI: 10.1083/jcb.200603063
PMCID: PMC2063860

Genes

SYCP2
SYCP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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