Article
Altered cohesin gene dosage affects Mammalian meiotic chromosome structure and behavior.
PLoS genetics - 1 Jan 2013
Murdoch Brenda, Owen Nichole, Stevense Michelle, Smith Helen, Nagaoka So, Hassold Terry, McKay Michael, Xu Huiling, Fu Jun, Revenkova Ekaterina, Jessberger Rolf, Hunt Patricia
Abstract excerpt
Based on studies in mice and humans, cohesin loss from chromosomes during the period of protracted meiotic arrest appears to play a major role in chromosome segregation errors during female meiosis. In mice, mutations in meiosis-specific cohesin genes cause meiotic disturbances and infertility. However, the more clinically relevant situation, heterozygosity for mutations in these genes, has not been evaluated. We...
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