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Article

Protamine 2 deficiency leads to sperm DNA damage and embryo death in mice.

Biology of reproduction - 1 Jul 2003

Cho Chunghee, Jung-Ha Haesook, Willis William D, Goulding Eugenia H, Stein Paula, Xu Zhe, Schultz Richard M, Hecht Norman B, Eddy Edward M

Abstract excerpt

Cytokinesis is incomplete in spermatogenic cells, and the descendants of each stem cell form a clonal syncytium. As a result, a heterozygous mutation in a gene expressed postmeiotically affects all of the haploid spermatids within a syncytium. Previously, we have found that disruption of one copy of the gene for either protamine 1 (PRM1) or protamine 2 (PRM2) in the mouse results in a reduction in the amount of...

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Source

Identifiers

PMID: 12620939
DOI: 10.1095/biolreprod.102.015115

Genes

PRM2
PRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Protamine 2 deficiency leads to sperm DNA damage and embryo death in mice.PMID 12620939Read ↗

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<i>Prm2</i> deficiency triggers a Reactive Oxygen Species (ROS)-mediated destruction cascade during epididymal sperm maturation in miceSemantic proximity Read ↗

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Loss of <i>Prm1</i> leads to defective chromatin protamination, impaired PRM2 processing, reduced sperm motility and subfertility in male miceSemantic proximity Read ↗

Transition nuclear proteins are required for normal chromatin condensation and functional sperm development.Semantic proximity Read ↗

DNA Integrity Is Compromised in Protamine‐Deficient Human SpermSemantic proximity Read ↗

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