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Article

Novel mutation in the UL97 gene of a clinical cytomegalovirus strain conferring resistance to ganciclovir.

Antimicrobial agents and chemotherapy - 1 May 1995

Hanson M N, Preheim L C, Chou S, Talarico C L, Biron K K, Erice A

Abstract excerpt

Characterization of a ganciclovir-resistant cytomegalovirus strain from a patient with AIDS showed a histidine-to-glutamine change at residue 520 of UL97 (Q520 mutation). In anabolism studies, Q520 was associated with impaired phosphorylation of ganciclovir. Transfer of Q520 to a recombinant virus resulted in a ganciclovir-resistant phenotype.

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Source

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Identifiers

PMID: 7625819
DOI: 10.1128/AAC.39.5.1204
PMCID: PMC162714

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Source receipt: pubmed, retrieved 7 Sept 2026.

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