Article
Novel mutation in the UL97 gene of a clinical cytomegalovirus strain conferring resistance to ganciclovir.
Antimicrobial agents and chemotherapy - 1 May 1995
Hanson M N, Preheim L C, Chou S, Talarico C L, Biron K K, Erice A
Abstract excerpt
Characterization of a ganciclovir-resistant cytomegalovirus strain from a patient with AIDS showed a histidine-to-glutamine change at residue 520 of UL97 (Q520 mutation). In anabolism studies, Q520 was associated with impaired phosphorylation of ganciclovir. Transfer of Q520 to a recombinant viru...
Topics
- AIDS-Related Opportunistic Infections
- Base Sequence
- Cytomegalovirus
- Drug Resistance, Microbial
- Ganciclovir
- Glutamine
- Histidine
- Humans
- Molecular Sequence Data
- Mutation
- Phenotype
- Polymerase Chain Reaction