Article
Mutations in human cytomegalovirus UL97 gene confer clinical resistance to ganciclovir and can be detected directly in patient plasma.
The Journal of clinical investigation - 1 Jan 1995
Wolf D G, Smith I L, Lee D J, Freeman W R, Flores-Aguilar M, Spector S A
Abstract excerpt
Specific mutations in the UL97 region of human cytomegalovirus (HCMV) have been found to confer resistance to laboratory-adapted strains subjected to ganciclovir selection. In this study, mutations in the UL97 region of HCMV isolates obtained from patients receiving ganciclovir therapy were examined to determine whether they would confer ganciclovir resistance, and if these mutations could be detected directly in...
Topics
- Acquired Immunodeficiency Syndrome
- Base Sequence
- Cytomegalovirus
- Cytomegalovirus Retinitis
- DNA, Viral
- Drug Resistance
- Ganciclovir
- Genetic Markers
- Humans
- Microbial Sensitivity Tests