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Article

Cytomegalovirus UL97 kinase catalytic domain mutations that confer multidrug resistance.

Antimicrobial agents and chemotherapy - 1 Jul 2013

Chou Sunwen, Ercolani Ronald J, Marousek Gail, Bowlin Terry L

Abstract excerpt

Human cytomegalovirus UL97 kinase mutations that commonly confer ganciclovir resistance cluster in different parts of the gene than those conferring resistance to maribavir, an experimental UL97 kinase inhibitor. The drug resistance, growth, and autophosphorylation phenotypes of several unusual UL97 mutations in the kinase catalytic domain were characterized. Mutations V466G and P521L, described in clinical...

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Identifiers

PMID: 23650173
DOI: 10.1128/AAC.00511-13
PMCID: PMC3697320

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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