Article
Cytomegalovirus UL97 phosphotransferase mutations that affect susceptibility to ganciclovir.
The Journal of infectious diseases - 15 Jan 2002
Chou Sunwen, Waldemer Rachel H, Senters Anne E, Michels Kevin S, Kemble George W, Miner Richard C, Drew W Lawrence
Abstract excerpt
Most ganciclovir (GCV)-resistant cytomegalovirus (CMV) isolates contain UL97 gene mutations at codon 460 or 520 or between codons 590 and 607, where an increasing variety of mutations have been detected, including deletions. To determine their phenotypic effect, 9 UL97 mutations not previously studied were transferred to drug-sensitive laboratory CMV strains that contained unique restriction sites developed for...
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