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Article

A three-nucleotide deletion in the UL97 open reading frame is responsible for the ganciclovir resistance of a human cytomegalovirus clinical isolate

1 Feb 1995

Abstract excerpt

Multiple human cytomegalovirus (HCMV) strains frequently coexist in patients with AIDS, and chronic ganciclovir treatment may favor the emergence of ganciclovir-resistant viral mutants. We report the molecular and biochemical characterization of a HCMV ganciclovir-resistant strain (VR3480) previously recovered from a patient with AIDS who was undergoing multiple courses of ganciclovir treatment (G. Gerna, F....

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Identifiers

PMID: 7815545
DOI: 10.1128/jvi.69.2.796-800.1995

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A three-nucleotide deletion in the UL97 open reading frame is responsible for the ganciclovir resistance of a human cytomegalovirus clinical isolatePMID 7815545Read ↗

Single amino acid changes in the DNA polymerase confer foscarnet resistance and slow-growth phenotype, while mutations in the UL97-encoded phosphotransferase confer ganciclovir resistance in three double-resistant human cytomegalovirus strains recovered from patients with AIDS.Semantic proximity Read ↗

Analysis of the UL97 phosphotransferase coding sequence in clinical cytomegalovirus isolates and identification of mutations conferring ganciclovir resistance.Semantic proximity Read ↗

Ganciclovir resistance and UL97 gene mutations in cytomegalovirus blood isolates from patients with AIDS treated with ganciclovir.Semantic proximity Read ↗

A nine-codon deletion mutation in the cytomegalovirus UL97 phosphotransferase gene confers resistance to ganciclovir.Semantic proximity Read ↗

Mutations in human cytomegalovirus UL97 gene confer clinical resistance to ganciclovir and can be detected directly in patient plasma.Semantic proximity Read ↗

Mutations in the human cytomegalovirus UL27 gene that confer resistance to maribavir.Semantic proximity Read ↗

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Mutation in the UL97 open reading frame of human cytomegalovirus strains resistant to ganciclovirSemantic proximity Read ↗

The genetic basis of human cytomegalovirus resistance and current trends in antiviral resistance analysis.Semantic proximity Read ↗

Sequencing of cytomegalovirus UL97 gene for genotypic antiviral resistance testing.Semantic proximity Read ↗

Genotypic characterization of human cytomegalovirus UL97 phosphotransferase natural polymorphism in the era of ganciclovir and maribavir.Semantic proximity Read ↗

Single and multiple mutations in the human cytomegalovirus UL97 gene and their relationship to the enzymatic activity of UL97 kinase for ganciclovir phosphorylation.Semantic proximity Read ↗

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